4-AcO-DMT (or psilacetin) is a semi-synthetic tryptamine closely related to the “magic mushroom” molecules psilocin and psilocybin. Like psilocybin, it appears to be metabolized by the body into psilocin. Most people buy psilacetin as a brown or off-white powder, but it’s also available in pills, tablets, capsules, and gel tabs among other preparations. Some trippers mix the powder with water just prior to dosing. While some find the effects indistinguishable from psilocybin mushrooms, others say it’s more like DMT. The difference may be dose-dependent. But mystical-type experiences are common, as are philosophical insights and a sense of empathic well-being.

When smoked, the average dose of DMT is believed to be somewhere between 30 to 150 milligrams (mg), and the onset of action can be felt almost instantly. The effects peak and plateau for 3 to 5 minutes, and gradually drop off with the duration of effect totaling 30 to 45 minutes.</p>